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September 3, 2020

Question of the Day – Thursday September 3, 2020

In a recent case report, canagliflozin is suspected to be the culprit of rosuvastatin myotoxicity. What is the theorized mechanism of this potential drug interaction?

 

In a recent case report, it is theorized that canagliflozin enhanced the absorption of rosuvastatin and inhibited both biliary and renal elimination through inhibition of the efflux transporter Brease Cancer Resistance Protein (BCRP).

Brailovski E et al. Rosuvastatin Myotoxicity After Starting Canagliglozin Treatment: A Case Report. Ann Intern Med 2020; published online 4 August 2020. https://doi.org/10.7326/L20-0549

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • 2025 ABAT Election Ballot
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      • Certification Renewal Documents
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      • ABAT Member Directory
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      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
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        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
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      • AACT Committee Leadership Opportunities
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