A recent double-blinded, randomized clinical trial comparing physostigmine (bolus and infusion) and benzodiazepines for the treatment of antimuscarinic delirium and agitation, found superior control of agitation and delirium after bolus dosing in which group?
According to the cited reference, physostigmine provided superior control of delirium and agitation after bolus dosing, as measured by the CAM-ICU and RASS scores, respectively. When compared with the lorazepam group, physostigmine-treated patients also had improved delirium after a 4-hour infusion, though physostigmine was not more effective in controlling agitation after the 4-hour infusion.
Wang GS, Baker K, Ng P, Janis GC, Leonard J, Mistry RD, Heard K. A randomized trial comparing physostigmine vs lorazepam for treatment of antimuscarinic (anticholinergic) toxidrome. Clin Toxicol (Phila). 2021 Aug;59(8):698-704. doi: 10.1080/15563650.2020.1854281. Epub 2020 Dec 9. PMID: 33295809.