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June 6, 2019

Question of the Day – Thursday June 6, 2019

Question - What are the three stages that characterize the so-called “purple glove syndrome (PGS)”?

Answer- The cited review of PGS describes “…three temporal stages of injury: initial painful blue-purple discoloration and edema around the IV catheter site, subsequent worsening of pain, edema, and discoloration with development of epidermal sloughing, ulceration, or bullae formation, and neuromuscular symptoms such as paresthesias or weakness, and eventually resolution of edema and discoloration starting from the periphery of the injury and moving toward the site of catheter insertion. Timing of these stages appears quite variable, with initial discoloration occurring from minutes to days after phenytoin administration and tissue recovery spanning days to months.” (Garbovsky LA et al. Purple glove syndrome after phenytoin or fosphenytoin administration: Review of reported cases and recommendations for prevention. 2015 J Med Toxicol 11:445-459)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
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      • Forensic
      • Pediatric
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