Which substance was responsible for causing the “Epping Jaundice” outbreak of 1965?
4,4′-methylenedianiline (MDA)
During February 1965, an outbreak of jaundice occurred in the Epping district of Essex, first identified in a medical student. In total, 84 cases were identified, which were later confirmed as having been in contact with a common source, consumption of bread baked with flour that had been contaminated during transportation with 4,4′-methylenedianiline (MDA), a curing agent for epoxy resin.
Nichols L. The Epping Jaundice Outbreak: mortality after 38 years of follow up. Int Arch Occup Environ Health 2004 Nov; 77(8); 592-594. doi: 10.1007/s00420-004-0565-7
Submitted by: Mary O’Keefe, PharmD
Posted in Question Of The Day