There has been much discussion currently about the use of hydroxychloroquine in the management of SARS-COV-2 infection. What was the main cardiac toxicity seen in a subset of patients treated with hydroxychloroquine and azithromycin?
In 84 patients treated with hydroxychloroquine and azithromycin, 30% of patients had an increase in their QTc by greater than 40 msec and 11% of the patients had a QTc greater than 500 msec. The QTc prolongation reached its maximum on days 3 and 4. (Chorin E et al. The QT interval in patients with SARS-COV-2 infection treated with hydroxychloroquine and azithromycin. doi: https://doi.org/10.1102/2020.04.02.20047050)
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