Historical QOD 12/10/08: Which cancer has been associated with the use of diethylstilbestrol?
Diethylstilbestrol (DES) is a transplacental carcinogen. Maternal use of this synthetic estrogen has been associated with vaginal cancer (clear cell adenocarcinoma) in female offspring. Approximately 0.1% of DES exposed offspring develop vaginal cancer, typically after the onset of puberty. DES exposure is also associated with reproductive tract structural abnormalities, pregnancy complications, and infertility in female offspring. Noncancerous epididymal cysts have been observed in male offspring.