Methylene blue has been suggested as a treatment for refractory vasodilatory shock by limiting nitric oxide-mediate vasodilation. A recent porcine model compared the efficacy of norepinephrine versus methylene blue on mortality. Was methylene blue associated with decreased mortality?
In a recent porcine model, LeRoy JM et al. compared norepinephrine versus methylene blue following amlodipine overdose. In this study, there was no difference in survival in the methylene blue treated porcine. It is important to mention that this model compared the two interventions to each other. Future study should be done comparing both norepinephrine and methylene blue to norepinephrine alone. (LeRoy JM et al. Effect of methylene blue on a porcine model of amlodipine toxicity. JMT 2020. Published online 3 June 2020. https://doi.org/10.1007/s13181-020-00780-w)