What agent is associated with severe diaper rash, skin breakdown, and blister formation after exploratory ingestions by children.
In 2003, a prospective case series from 6 poison centers suggested an approximately 33% risk of severe rash and 11% skin breakdown and blisters in children with diarrhea.
Spiller HA, Winter ML, Weber JA, et al. Skin breakdown and blisters from senna-containing laxatives in young children. Ann Pharmacother. 2003;37(5):636-639.
Contributed by: Jimmy Leonard, PharmD on behalf of the University of Maryland