Which dye routinely used in medical imaging has been suggested as a possible antidote for amatoxin?
Indocyanine green. The referenced article utilized a combined approach using genome-wide CRISPR screening
coupled with in silico drug prediction to identify new antidotes for medically relevant human poisons. Indocyanine green was identified as an inhibitor of STT3B which is necessary for N-glycan biosynthesis. N-glycan is necessary for protein folding and trafficking and may inhibit the toxic effect of amatoxin.
Wang B, Wan AH, Xu Y, Zhang RX, Zhao BC, Zhao XY, Shi YC, Zhang X, Xue Y, Luo Y, Deng Y, Neely GG, Wan G, Wang QP. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. Nat Commun. 2023 May 16;14(1):2241. doi: 10.1038/s41467-023-37714-3. PMID: 37193694; PMCID: PMC10188588.