Question - What is the typical clinical course following a brown recluse spider bite?
Answer- The cited article states “A typical bite exhibits a characteristic pattern that includes pruritis, pain, and erythema within 6 h, and an irregular, erythematous ring that demarcates the bite by 24 h. In more severe cases, necrosis can be seen within 48–72 h. Early signs of necrosis are hyperesthesia, bullae, and cyanosis, leading to an ulcer that is red-blue in color, painful, and covered by an eschar. The severity of the lesion does not correlate to developing systematic loxoscelism.” (Andersen RJ et al. Suspected brown recluse envenomation: A case report and reviewed of different treatment modalities. 2011 J Emerg Med 41(2): e31-e37)