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January 10, 2019

Question of the Day – Thursday January 10, 2019

Question - The article cited below notes melasma is “a common, acquired skin condition that is characterized by symmetric, irregular brown or grayish brown patches on sun-exposed areas such as the forehead and malar prominences and less commonly the neck and forearms.” The most common treatment for melasma involves topical applications of the chemical hydroquinone to induce hypopigmentation. What is the mechanism for this effect?

Answer- According to the cited article, “Hydroquinone exerts pleiotropic hypopigmenting effects via weak inhibition of tyrosinase, potent cytotoxicity toward melanocytes, degradation of melanosomes, depletion of glutathione, and inhibition of DNA and RNA synthesis.” (Jow T and Hantash BM. Hydroquinone-induced depigmentation: case report and review of the literature. 2014 Dermatitis 25(1): e1-e5)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • 2023 ABAT Board of Directors Voting
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
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    • Register
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