In a recent animal model of diethylene glycol poisoning, neurologic injury and accumulation of diglycolic acid occurred in rats that concurrently had this finding?
Acute kidney injury. Jamison et al. showed that after diethylene glycol poisoning, diglycolic acid (DGA) accumulated in the brain only in animals that developed acute kidney injury and neurological injury.
Jamison CN et al. Neurotoxic effects of nephrotoxic compound diethylene glycol.Clin Tox 2021; Epub. https://doi.org/10.1080/15563650.2021.1874403