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The American Academy of Clinical Toxicology
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August 12, 2021

Question of the Day – Thursday August 12, 2021

In a recent rabbit model of oral cyanide poisoning, oral sodium thiosulfate and glycine improved survival. What is the proposed mechanism for the effect of glycine?

The authors hypothesize that after ingestion of cyanide, hydrogen cyanide is rapidly formed due to the acidic pH of the stomach, and glycine may cause a buffering effect which results in a decreased production of hydrogen cyanide in the stomach.

Brenner M et al. Oral glycine and sodium thiosulfate for lethal cyanide ingestion. Clin Tox 2017; 7(3): 355. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578424/

Posted in Question Of The Day
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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • Meeting Information
    • Abstract Submissions
    • After the Fact CE
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