In a recent rabbit model of oral cyanide poisoning, oral sodium thiosulfate and glycine improved survival. What is the proposed mechanism for the effect of glycine?
The authors hypothesize that after ingestion of cyanide, hydrogen cyanide is rapidly formed due to the acidic pH of the stomach, and glycine may cause a buffering effect which results in a decreased production of hydrogen cyanide in the stomach.
Brenner M et al. Oral glycine and sodium thiosulfate for lethal cyanide ingestion. Clin Tox 2017; 7(3): 355. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578424/