What intervention was associated with less severe myotoxicity in Australian patients with snake envenomation?
Antivenom given before the development of elevated creatine kinase (CK). A retrospective analysis of 1638 patients with snake envenomation in Australia identified 148 (16%) with myotoxicity (CK > 1000 IU/L). Patients administered antivenom prior the first abnormal CK (> 500 U/L) had median peak CK 2976 U/L compared to 7590 U/L in patients that received antivenom after the first abnormal CK (p=.008).
Johnston CI, et al. Australian snakebite myotoxicity (ASP-23). Clin Toxicol (Phila) 2020, DOI: 10.1080/15563650.2020.1836377