Hi Everyone, We apologize for not sending out the QOD this past week. So, in an effort to make it up to you, we will have QOD released this weekend and next weekend. Thanks for your understanding!
Question: What are the three key strategies used to treat methotrexate toxicity?
Answer- The cited article describes three key strategies used to treat methotrexate toxicity as follows: “…enhance renal elimination by giving intravenous fluids and alkalinizing the urine, bypass the blocked dihydrofolate reductase enzyme to restart the DNA synthesis process by giving folinic acid (leucovorin) and add glucarpidase to the mix to cleave and inactivate the methotrexate molecules.” (Vohra R et al. Working through the paradox of methotrexate toxicity. 2018 Ann Emerg Med 76(2): 129-132)