Question -Hydroxyurea (hydrooxycarbamide) is an antineoplastic drug sometimes used in the treatment of myeloproliferative disorders as well as in a variety of malignancies. The most common toxicities attributed to the use of this drug include bone marrow failure and associated pancytopenia. What are the potential pulmonary toxicities associate with the use of this drug?
Answer- The cited article notes that “hydroxycarbamide can induce lung toxicity with pulmonary edema and lung infiltration” with resultant pulmonary fibrosis. (Bargagli E., et al. Fibrotic lung toxicity induced by hydroxycarbamide. 2017 In Vivo. 31:1221-1223)
Question 1-Hydroxyurea (hydrooxycarbamide) is an antineoplastic drug sometimes used in the treatment of myeloproliferative disorders as well as in a variety of malignancies. The most common toxicities attributed to the use of this drug include bone marrow failure and associated pancytopenia. What are the potential pulmonary toxicities associate with the use of this drug?