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November 18, 2019

Question of the Day – Monday November 18, 2019

Question - The development of megaloblastic anemia has been attributed to both congenital and acquired problems. What is the general mechanism for the development of drug-induced (acquired) megaloblastic anemia?

 

 

Answer- The cited article notes “Drugs cause megaloblastic anemia by impairing the cellular availability or use of folic acid or vitamin B12. This may occur because of interference with the absorption, plasma transport, or delivery of folate or vitamin B12, competition for reducing enzymes, end-product inhibition of cofactor-mediated reactions, or physical destruction of the vitamins.” (Hesdorffer CS and Longo DL. Drug-induced megaloblastic anemia. 2015 NEJM 373:1649-1658)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
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    • Abstract Submissions
    • After the Fact CE
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