Aprepitant is currently being investigated as a potential treatment for chemotherapy induced nausea and vomiting. What is the mechanism of action of aprepitant?
Aprepitant is a neurokinin-1 receptor antagonist and selectively blocks the binding of substance P at the neurokinin 1 receptor in the central nervous system. In a recent phase 3 trial of 248 women receiving moderately emetegonic chemotherapy, the addition of aprepritant to palonosetron and dexamethasone was effective in reducing nausea and vomiting.
Wang DS et al. Effect of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and vomiting in Women: A Randomized Clinical Trial. JAMA Netw Open. 2021;4(4):e215250. doi:10.1001/jamanetworkopen.2021.5250