Question - Cisplatin is an antineoplastic drug that may be used in the treatment of a variety of solid organ cancers. What is the primary does-limiting toxicity associated with the use of this drug?
Answer - The primary dose-limiting toxicity associated with the use of cisplatin is nephrotoxicity. (Miller RP et al. Mechanisms of cisplatin nephrotoxicity. 2010 Toxins 2:2490-2518.)