An elevated trough concentration of cefepime results in this adverse effect?
Elevated serum trough concentrations of cefepime are associated with neurotoxicity. In one retrospective study by Boschung-Pasquier L et al, no patients that had trough concentrations of < 7.7 mg/L had neurotoxicity while all patients with trough concentrations of > 38.1 mg/L had neurotoxicity. 50% of patients with trough concentrations > 16 mg/L had neurotoxicity. Boschung-Pasquier L et al suggest that trough concentrations of cefepime be less than 7.5 mg/L to avoid the risk of neurotoxicity. (Boschung-Pasquier L et al. Cefepime neurotoxicity: thresholds and risk factors. A retrospective cohort study. Clinical Microbiology and Infection. 2019 Ahead of print. DOI: https://doi.org/10.1016/j.cmi.2019.06.028)
An elevated trough concentration of cefepime results in this adverse effect?