What food additive resulted in increased clearance of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)?
Olestra. Initially investigated as a dietary fat substitute, olestra administration resulted in clearance rates 8-10 times higher in 2 patients with TCDD exposure.
Contributor: Rachel Schult, PharmD, DABAT, University of Rochester Medical Center
Geusau A, et al. Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Lancet 1999;354(9186):1266-7. doi: 10.1016/S0140-6736(99)04271-3.