In a recent study evaluating the use of high dose NAC for massive acetaminophen overdose, was there a statistically significant difference in outcome compared to standard dose?
This study was unable to identify a statistically significant difference between high dose and standard dose NAC used for massive acetaminophen ingestion, even when initiated within 8 hours of ingestion.
Lewis JC, Lim M, Lai L, Mendoza E, Albertson TE, Chenoweth JA. Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion. Clin Toxicol (Phila). 2021 Sep 28:1-7
Submitted by: Molly Stott, PharmD and Dawn Sollee, PharmD, DABAT