In a case report published in 2014, of anticholinergic agitation refractory to 12mg of lorazepam over a 5 hour span what pharmacological agent was administered that resulted in improvement in anticholinergic induced agitation?
Dexmedetomidine was given for 25 hours then discontinued, agitation returned and patient was restarted on the infusion for additional 8 hours. The infusion was discontinued again with out return of symptoms.
Walker A, Delle Donne A, Douglas E, Spicer K, Pluim T. Novel use of dexmedetomidine for the treatment of anticholinergic toxidrome. J Med Toxicol. 2014 Dec;10(4):406-10. doi: 10.1007/s13181-014-0408-1. PMID: 24943229; PMCID: PMC4252285.
Contributed by: Florida/USVI Poison Information Center- Jacksonville, Toxicology Fellowship Program