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April 30, 2018

Question of the Day – Monday April 30, 2018

Question - Some have proposed the use of topical capsaicin for the symptomatic relief of symptoms in the cannabinoid hyperemesis syndrome (CHS). What is the proposed mechanism for the efficacy of capsaicin in this setting?

Answer: The cited reference notes “capsaicin binds to transient reception potential vanilloid-1 receptors (TRPV1) found widely throughout the body, often in proximity to CB-1 receptors and thus suggesting a functional interaction. Such areas include the medullary vomiting center and the GI tract. The TRPV1 receptors are also activated by low pH and high temperature and they may regulate release of substance P, an important mediator of nausea and emesis from sensory nerves. As such, TRPV1 receptors may play a teleological role in the efficacy of hot showers/baths for symptomatic relief of CHS”. (Richards JR et al. Pharmacologic treatment if cannabinoid hyperemesis syndrome: A systematic review. 2017 Pharmacotherapy 37(6): 725-734)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
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      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
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      • Occupational / Environmental
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