A recent prospective study of patients suffering Carbon Monoxide toxicity found an association between corticosteroid threatment and a lower incidence of Delayed Neurological Sequelae. What was the dosing regimen used in this study?
The investigators used 10 mg intravenous dexamethasone every 24 hours for 3 doses. Cardiovascular disease, diabetes, glaucoma, or an infectious disease were considered contraindications.
Kim S, Choi S, Ko Y, Lee CA, Kim GW, Moon JE, Nah S, Han S. Dexamethasone therapy prevents delayed neuropsychiatric sequelae after carbon monoxide poisoning: a prospective registry-based study. Clin Toxicol (Phila). 2023 Feb 6:1-6. doi: 10.1080/15563650.2023.2169707. Epub ahead of print. PMID: 36744989.