Question - What are the relevant receptors involved in cannabinoid activity?
Answer - The cited reference notes “Cannabinoids are a class of chemical compounds of diverse origins that act on the cell membrane cannabinoid receptors belonging to the rhodopsin-like G-protein coupled receptor (GPCR) family and are subdivided into two subtypes: cannabinoid receptor 1(CB1R, mainly expressed in the brain and altering neurotransmitter release) and cannabinoid receptor 2 (CB2R, particularly abundant in immune tissues and modifying cytokine release) receptors.”
“Three major groups of cannabinoid receptor ligands have been identiﬁed: endocannabinoids (the most clearly deﬁned, anandamide and 2-arachydonylglycerol) produced by mammalians, phytocannabinoids (particularly D9-tetrahydrocannabinol (D9-THC), the most psychoactive, and cannabidiol, non-psychoactive) produced by the cannabis plant, and a number of synthetic cannabinoids (SCs) sold for recreational drug use.” (Le Boisselier R. et al. Focus on cannabinoids and synthetic cannabinoids. 2017 Clin Pharm Ther 101(2):220-229)