Drug toxicity or therapeutic failure can occur if transgender patients receive medication doses inconsistent with their current physiology. According to a recent article on drug dosing in transgender patients, how should creatinine clearance and ideal body weight calculations be determined for patients on hormone therapy?
The cited reference recommends dosing medications based on CLcr and IBW calculations consistent with gender identity after a patient has been on hormone therapy for 6 months or longer.
Webb AJ, McManus D, Rouse GE, Vonderheyde R, Topal JE. Implications for medication dosing for transgender patients: A review of the literature and recommendations for pharmacists. Am J Health Syst Pharm. 2020 Mar 5;77(6):427-433. doi: 10.1093/ajhp/zxz355. PMID: 32012216.