What are some factors which affect absorption in rectally administered aspirin?
Formulation of aspirin, intestinal pH, and surface area all affect the rate of absorption of rectal aspirin. In absorption of aspirin, the rate limiting factor is particle dissolution. In more highly acidic environments, more aspirin is present in the unionized form which is more rapidly absorbed across mucous membranes.
Watson, Jerry E., and Eumar T. Tagupa. “Suicide Attempt by Means of Aspirin Enema.” Annals of Pharmacotherapy, vol. 28, no. 4, 1994, pp. 467–469
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