A study was performed on data from the US Department of Veterans Affairs on 7.9 million persons without preexisting liver or biliary disease who
initiated a suspected hepatotoxic medication in the outpatient setting. Which drugs were considered responsible for more than 10 epidosodes of acute liver injury per
10,000 person-years?
Stavudine, erlotinib, lenalidomide or thalidomide, chlorpromazine, metronidazole, prochlorperazine, and isoniazid were implicated in more than 10 events per 10,00 person-years.
Torgersen J, Mezochow AK, Newcomb CW, Carbonari DM, Hennessy S, Rentsch CT, Park LS, Tate JP, Bräu N, Bhattacharya D, Lim JK. Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data. JAMA internal medicine. 2024 Jun 24.
Contributed by Kristine Nanagas, MD