What kind of reproductive toxicity was seen in Swiss male mice after chronic exposure to cannabidiol (CBD)?
There was a decrease in total circulating testosterone by 76% (still within normal physiological range), an increase sperm head abnormalities, and a 38% reduction in the amount of spermatozoa in the epididymis tail. These changes suggest a risk of male reproductive toxicity with chronic CBD use.
Carvalho RK, Santos ML, Souza MR, Rocha TL, Guimarães FS, Anselmo-Franci JA, Mazaro-Costa R. Chronic exposure to cannabidiol induces reproductive toxicity in male Swiss mice. J Appl Toxicol. 2018 Sep;38(9):1215-1223. doi: 10.1002/jat.3631. Epub 2018 May 16. Erratum in: J Appl Toxicol. 2018 Dec;38(12):1545. PMID: 29766538.
Submitted by: Katelyn McTaggart, Pharmacy Student on behalf of Herbs & Dietary Supplements Section