What is the clinical significance of the drug interaction between valproate and carbapenem antibiotics?
Carbapenem antibiotics decrease serum valproate concentrations within 1-3 days after treatment initiation of the carbapenem. In a recent meta analysis, the mean reduction of valproate concentrations was 43.98 mg/L. Seizure frequency increased by 26.3% during combination therapy.
Chai PYC et al. Effect of drug interactions between carbapenems and valproate on serum valproate concentration: a systematic review and meta-analysis. Expert Opinion 2021; 20(2). https://doi.org/10.1080/14740338.2021.1865307