Question - Drug induced changes in hair color have been widely reported. What drugs have been associated with the development of hair hypopigmentation and which drugs have been associated with hair darkening?
Answer- The cited article reports “Hypopigmentation of hair color has been reported with sunitinib, chloroquine, IFN-α, cyclosporine A and etretinate. By contrast, hair darkening has been reported with imatinib, estrogens, prostaglandin analogs and tamoxifen. Hair can seem to be darker with chemotherapeutic agents like methotrexate and sunitinib, which can cause alternating bands of color known as the flag sign.” (Patel S and Tosti A. An overview of management of drug-induced hair and nail disorders. 2014 Clin Prac 11(3): 327-339)