Emerging evidence suggests that liver injury from some supplements may be immune mediated. Which herbal supplements has this been suggested recently?
HLA allele B*35:01 has been associated with drug induced liver injury from herbal supplements including: Green tea extract; turmeric and Garcinia cambogia.
1. Hoofnagle JH et al. HLA-B*35:01 and Green Tea-Induced Liver Injury. Hepatology 2021 Jun; 73(6): 2484-2493. PMID 32892374; 2. Vuppalanchi R et al. Garcinia cambogia, either alone or in combination with green tea, causes moderate to severe liver injury. Clin Gastroenterol Hepatol 2022 June 20(6): e1416-1425. PMID 34400337; 3. Halegoua-DeMarzio D et al. Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug Induced Liver Injury Network. Am J Med 2023 Feb; 136(2): 200-206. PMID 36252717.