In a simulated dialytic removal model, infusion of this drug resulted in the reduction of hemodialysis time to reach therapeutic concentration of carbamazepine from 265 to 220 minutes.
Maheshwari V et al. describes an innovative way to infuse a competitor drug into the extracorporeal circuit that increases its dialytic removal. They simulated phenytoin and carbamazepine and found that ibuprofen infusion reduced the HD time for carbamazepine to reach therapeutic concentration from 265 to 220 minutes.
Maheshwari V et al. A model-based analysis of phenytoin and carbamazepine toxicity treatment using binding-competition during hemodialysis. Nature 2020; 10: 111294. doi.org/10.1038/s41598-020-68333-3