In a retrospective study of 26 patients with a therapeutic valproic acid (VPA) concentration, what percentage decrease in the concentration occurred after the administration of meropenem?
There was a decrease in VPA concentrations of 67%±19% after the administration of meropenem.
Wu CC, Pai TY, Hsiao FY, Shen LJ, Wu FL. The effect of different carbapenem antibiotics (ertapenem, imipenem/cilastatin, and meropenem) on serum valproic acid concentrations. Therapeutic drug monitoring. 2016 Oct 1;38(5):587-92.
Contributed by: Kristine Nanagas, MD
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