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April 29, 2022

Question of the Day – Friday, April 29, 2022

What factors might explain higher sensitivity of urine for detection of buprenorphine when compared to oral fluid?

The detection window of buprenorphine is presumably longer in urine; the timing of drugs in oral fluid is similar to plasma and therefore less indicative of remote use. Also, concentrations of oral fluid norbuprenorphine are typically much lower than oral fluid buprenorphine, and the buprenorphine and norbuprenorphine glucuronide metabolites are not present in oral fluid.

Ransohoff JR, Petrides AK, Piscitello GJ, Flood JG, Melanson SEF. Urine is superior to oral fluid for detecting buprenorphine compliance in patients undergoing treatment for opioid addiction. Drug Alcohol Depend. 2019 Oct 1;203:8-12. doi: 10.1016/j.drugalcdep.2019.06.015. Epub 2019 Aug 1. PMID: 31394416

Posted in Question Of The Day
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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • 2025 ABAT Election Ballot
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
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        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
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      • Addiction Toxicology Section
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