What is the duration of the analgesic effect of methadone compared to the withdrawal prevention effect?
The duration of analgesia is 4-6 hours initially; with repeat dosing, 8-12 hours. The duration of withdrawal prevention is 30-60 hours
Katzung K, Laes J, Weigand T. 2023 ACMT Annual Scientific Meeting, ASAM Panel. Tricks of the Trade: Pain and Perioperative Management in Patients with OUD