Typically, we think of seizures related to a hydrazine exposure because of interference in pyridoxal-5-phosphate dependent GABA synthesis. In a systematic review of the literature on acute hydrazine propellant exposure what other organ systems are targets of hydrazine toxicity?
Dermal irritation and caustic injury, pulmonary edema, hepatotoxicity, methemoglobinemia and hemolytic anemia.
Nguyen HN, Chenoweth JA, Bebarta VS, Albertson TE, Nowadly CD. The Toxicity, Pathophysiology, and Treatment of Acute Hydrazine Propellant Exposure: A Systematic Review. Mil Med. 2021 Feb 26;186(3-4):e319-e326. doi: 10.1093/milmed/usaa429. PMID: 33175959.
Submitted by: VCU Medical Toxicology Fellowship
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