Question: What is BPA?
Answer: The cited reference notes “BPA is an estrogenic compound. It has a similar structure as the highly potent estrogen receptor (ER) agonist, diethylstilbestrol (DES), and binds classical nuclear ER alpha and beta, as well as membrane-associated GPR30, albeit with lower affinity. Thus, BPA is expected to have effects on ER function in addition to other nuclear hormone receptors and most of the studies on BPA action have focused on hormone sensitive tissues. The ubiquitous presence of BPA in the environment, concomitant with the increased prevalence of endocrine-related cancers, has led to numerous studies evaluating the role of BPA in carcinogenesis. (Seachrist DD et al. A review id the carcinogenic potential of bisphenol A. 2016 Reproductive Tox 59:167-182)