Question: Valproic acid is often sued in the management of chronic seizure disorders and for bipolar disease as well as in the preventive management of migraine headaches. In which clinical circumstances has levocarnitine been proposed to manage overdoses of valproic acid?
Answer: Levocarnitine has been proposed as part of the treatment regimen for patients with hyperammonemia, comatose patients and those with increasing blood levels (>400 mg/dl) (Sun C. Valproic acid. 2017 Critical Decisions in Emerg Med. 31(1):24)