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November 28, 2017

Question of the Day – Tuesday November 28, 2017

Question: Which adverse clinical consequences associated with the use of quinidine resulted in the U.S. Food and Drug Administration prohibiting the off-label use of this drug to treat leg cramps?

Answer: The cited reference notes “Quinidine causes a drug-dependent, antibody-mediated thrombotic microangiopathy. The occurrence of arrhythmias, thrombocytopenia and thrombotic microangiopathy in association with quinidine intake prompted the Food and Drug Administration to prohibit its off-label use to treat leg cramps. (Dhaliwal G et. al. Case 36-2017: A 30-year-old man with fatigue rash, anemia and thrombocytopenia. 2017 NEJM 377(21):2074-2083).

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • 2023 ABAT Board of Directors Voting
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • Meeting Information
    • Register
    • After the Fact CE
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