Question- What is the name of the neurotoxic syndrome occurring in approximately 10% of individuals taking calcineurin inhibitors?
Answer- The “posterior reversible encephalopathy syndrome” occurs in approximately 10% of individuals taking calcineurin inhibitors. The cited reference notes that this syndrome is characterized by “headaches, confusion, vision abnormalities and seizures. While the specific pathophysiology for this syndrome is unknown “endothelial injury and vasogenic edema due to the failure of cerebral autoregulation have been described as a potential mechanism.” (El-Jawahri AR et al. Case 5-2018: A 63-year-old man with confusion after stem cell transplantation. 2018 NEJM 378(7):659-669)