Skip to content
The American Academy of Clinical Toxicology
  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • Meeting Information
    • Abstract Submissions
    • After the Fact CE
  • Research Grants
    • AACT Research Award
    • AACT Knowledge Translation Grant Award
    • Junior Investigator Research Grant
    • Gary S. Wasserman, DO, FAACT Memorial Pediatric Abstract Award
    • Toxicology Trainee Research Grant
    • Student and Trainee Travel Award
    • Lampe-Kunkel Memorial Award
  • Resources
    • Event Calendar
    • AACT Mobile App
    • Publications
      • AACTion
      • Abstracts
      • Clinical Toxicology Journal
      • Question of the Day
      • News
      • Current Awareness in Clinical Toxicology
      • Toxicology Today
      • Out of Hospital Guidelines
    • Toxicology Information
    • Affiliated Organizations
    • Press Resources
    • Job Opportunities
    • Online Store
  • About Us
    • Mission & Strategic Plan
    • Board of Trustees
    • Our History
    • Membership
      • AACT Member Directory
    • Award Recipients
    • Contact Us
  • Contact Us
  • Renew
  • Donate
  • Journal Access
The American Academy of Clinical Toxicology
Member LoginJoinContact
  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • Meeting Information
    • Abstract Submissions
    • After the Fact CE
  • Research Grants
    • AACT Research Award
    • AACT Knowledge Translation Grant Award
    • Junior Investigator Research Grant
    • Gary S. Wasserman, DO, FAACT Memorial Pediatric Abstract Award
    • Toxicology Trainee Research Grant
    • Student and Trainee Travel Award
    • Lampe-Kunkel Memorial Award
  • Resources
    • Event Calendar
    • AACT Mobile App
    • Publications
      • AACTion
      • Abstracts
      • Clinical Toxicology Journal
      • Question of the Day
      • News
      • Current Awareness in Clinical Toxicology
      • Toxicology Today
      • Out of Hospital Guidelines
    • Toxicology Information
    • Affiliated Organizations
    • Press Resources
    • Job Opportunities
    • Online Store
  • About Us
    • Mission & Strategic Plan
    • Board of Trustees
    • Our History
    • Membership
      • AACT Member Directory
    • Award Recipients
    • Contact Us
  • Contact Us
March 29, 2018

Question of the Day – Thursday March 29, 2018

Question- What is the so-called “vanishing bile duct syndrome” (VBDS) and which medications have been associated with this disorder?

Answer- The cited article notes- “Vanishing bile duct syndrome, also referred to as ductopenia, is defined by the histologic appearance on liver biopsy: the absence of interlobar bile ducts in 50% or more small portal tracts, with characteristic sparing of the larger extrahepatic biliary tree. It results from the destruction of intrahepatic bile ducts and their progressive disappearance from the liver parenchyma. Over 40 medications have been associated with causing VBDS, including chlorpromazine, ajmaline and arsenical derivatives, phenytoin, clindamycin, trimethoprim-sulfamethoxazole, and tetracyclines. More commonly, these medications cause varying degrees of drug-induced cholestasis. (Levine C et .al. Severe ductopenia and cholestasis from levofloxacin drug induced liver injury: A case report and review.2014 Sem Liver Dis 34:246-251.)

 

Posted in Question Of The Day
Share this

Recent Posts

  • Question of the Day – Thursday, March 30, 2023
  • Question of the Day – Wednesday, March 29, 2023
  • Question of the Day – Tuesday, March 28, 2023
  • Question of the Day – Monday, March 27, 2023
  • Question of the Day – Friday, March 24, 2023

Site Search

Get Involved

Volunteer for a committee, as a section chair, student chapter mentor, author Question of the Day and more!

Volunteer

Support AACT

Become a ‘Friend of the Academy’ through a tax-deductible financial contribution. Donating is just a text away!

Make a Contribution
aact-footer-logo

American Academy of Clinical Toxicology
6728 Old McLean Village Drive
McLean, VA 22101

Twitter

Privacy Policy

  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
    • Meeting Information
    • Abstract Submissions
    • After the Fact CE
  • Research Grants
    • AACT Research Award
    • AACT Knowledge Translation Grant Award
    • Junior Investigator Research Grant
    • Gary S. Wasserman, DO, FAACT Memorial Pediatric Abstract Award
    • Toxicology Trainee Research Grant
    • Student and Trainee Travel Award
    • Lampe-Kunkel Memorial Award
  • Resources
    • Event Calendar
    • AACT Mobile App
    • Publications
      • AACTion
      • Abstracts
      • Clinical Toxicology Journal
      • Question of the Day
      • News
      • Current Awareness in Clinical Toxicology
      • Toxicology Today
      • Out of Hospital Guidelines
    • Toxicology Information
    • Affiliated Organizations
    • Press Resources
    • Job Opportunities
    • Online Store
  • About Us
    • Mission & Strategic Plan
    • Board of Trustees
    • Our History
    • Membership
      • AACT Member Directory
    • Award Recipients
    • Contact Us
  • Contact Us

© 2023 American Academy of Clinical Toxicology | Sitemap

Website by Yoko Co

Scroll To Top