Question: Which anti-arrythmic drug has been associated with a so-called “pancerebellar syndrome” associated with “nystagmus, dysmetria, titubation, and ataxia of gait and stance”?
Answer: The cited reference notes: “Amiodarone appears to be associated with cerebellar toxicity. A pan-cerebellar syndrome with nystagmus, dysmetria, titubation, and ataxia of gait and stance occurred. Symptoms tended to resolve gradually over the course of weeks after drug withdrawal. There was a strong dose-dependent effect.” (Van Gaalen J et al. Drug-induced cerebellar ataxia: a systematic review. 2014 CNS Drugs 28:1139-1153)