Question: What is mexedrone?
Answer: The cited reference notes “Mexedrone, 3-methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one, is the alpha-methoxy-derivative of mephedrone (4-methyl-N-methyl cathinone). These authors point out “Whilst there are no published pharmacological studies of mexedrone, based on in vitro and in vivo studies of mephedrone, it can be anticipated that mexedrone inhibits the re-uptake of serotonin and dopamine in a dose-dependent manner and has affinity for serotonin and dopamine membrane transporters and receptors (5-HT2 and D2 receptors), producing sympathomimetic effects similar to amphetamines.” (Roberts L et al. 11 analytically confirmed cases of mexedrone use among polydrug users. 2017 Clin Tox 55(3):181-186)