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June 12, 2017

Question of the Day – Monday June 12, 2017

Question: Despite some warnings to the contrary, lithium is often used a treatment for bipolar disorder in females of child bearing age. During the first trimester of pregnancy, maternal use of lithium is associated with an increased risk in which category of fetal malformations?

Answer: Maternal use of lithium is associated with an increased risk of cardiac malformations, including Ebstein’s anomaly. However, the cited study of more than 1,300,000 pregnancies reported approximately “1 additional case [of cardiac malformations] per 100 live births when there was exposure early in pregnancy and that this association is dose dependent. (Patorno E et al. Lithium use in pregnancy and the risk of cardiac malformations. 2017 NEJM 376(23):2245-2254)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • AACT Fundamentals of Toxicology Research Seminar
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
    • Sections
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      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • BRIDGES Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
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