Question: Occupational exposure to the chemical carbon disulfide has been associated with a wide variety of adverse health effects including accelerated atherosclerosis in some workers. What phenomena have been posited as surrogate markers for the absorption of a medically important dose of carbon disulfide?
Answer: The cited article mentions that urinary 2-thiol-1,3-thiazolidine-carboxylic acid (TTCA) levels and/or the presence of ocular microaneurysms may serve as indicators of significant carbon disulfide exposure. (Sulsky SI et al. Critical review of the epidemiological literature on the potential cardiovascular effects of occupational carbon disulfide exposure. 2002 Int Arch Occup Environ Health 75:365-380)