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January 16, 2017

Question of the Day – Monday January 16, 2017

Question: Lithium is widely used as long-term therapy for bipolar disorder. What are the clinically important adverse risks for patients on long-term lithium therapy?

Answer: According to one systematic review and meta-analysis of randomized controlled trials and observational studies (more than 385 studies included): “Lithium is associated with increased risk of reduced urinary concentrating ability, hypothyroidism,

hyperparathyroidism, and weight gain. There is little evidence for a clinically significant reduction in renal function in most patients, and the risk of end-stage renal failure is low. The risk of congenital malformations is uncertain; the

balance of risks should be considered before lithium is withdrawn during pregnancy. Because of the consistent finding of a high prevalence of hyperparathyroidism, calcium concentrations should be checked before and during treatment.” (McKnight RF et al. Lithium toxicity profile: a systematic review and meta-analysis. 2012 Lancet 379:721-728)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • 2025 ABAT Election Ballot
      • ABAT Travel Grant
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • AACT Antidote Collective
    • E-Learning
      • Research Seminar: The Nuts and Bolts of Toxicology Research
      • Advanced Hazmat Life Support Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • ToxCoach Mentorship Program
    • Committees
      • AACT Committee Leadership Opportunities
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
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