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February 6, 2017

Question of the Day – Monday February 6, 2017

Question: What characterizes the orolingual angioedema associated with the administration of tissue plasminogen activator?

Answer: According to the cited reference, “orolingual angioedema is a rare adverse effect of tissue plasminogen activator (tPA) treatment of acute ischemic stroke with a reported incidence of between 1% and 5%. The frontal, insular, and peri-insular regions are often involved and are believed to play a role in the pathophysiology of stroke-associated angioedema…..Orolingual angioedema developing after tPA administration for acute ischemic stroke may manifest as unilateral swelling of the lips tongue and face. The resultant edema is commonly contralateral to the ischemic lesion that is believed to be due to the infarction’s triggering autonomic dysfunction and vasomotor changes in the hemiparetic side. Despite this distinct presentation, available literature has demonstrated equal representation of bilateral, contralateral and ipsilateral edema.” (Pahs L et al. A novel approach to the treatment of orolingual angioedema after tissue plasminogen activator administration. 2016 Ann Emerg Med 68(3):345-348)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
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      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
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