Question: Listeriosis is caused by the Gram-positive organism, Listeria monocytogenes. This bacterium generally causes self limited and mild gastroenteritis. What is the disease profile often associated with Listeria monocytogenes infections in at risk populations (e.g. pregnant women, elderly people, immuno-compromised people, unborn babies, and neonates) with possible inadequate cell mediated immunity?
Answer: The cited reference reports: “Mainly in patients with impaired cell-mediated immunity, listeriosis can lead to severe illnesses, including severe sepsis, meningitis, or encephalitis, and thereby cause lifelong consequences and even death. Infection during pregnancy can result in spontaneous abortions or stillbirths. Preterm birth is also a common consequence of listeriosis in pregnant women.” (de Noordhout CM et al. The global burden of listeriosis: a systematic review and meta-analysis. 2014 The Lancet Infectious Diseases 14:1073-1082)